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KMID : 0900920000240010035
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Korean journal of Animal Reproduction
2000 Volume.24 No. 1 p.35 ~ p.40
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Effect of Suckling on Serum Insulin-like Growth Factor- I Levels in the Primiparous Rat
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Oh Seok-Doo
Seong Hwan-Hoo
Min Kwan-Sik
Yun Chang-Hyeon
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Abstract
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This experiment was conducted to investigate how restricted-lactation and regulation of weaning-time influence the levels of insulin-like growth factor-I (IGF-I) in primiparous rats during the suckling period. All the rats were raised in the individual cage from a few days before parturition through the whole suckling period. The restrictedlactation (RL) and weaned (W) groups were subdivided into 5 subgroups as RL0, RL5, RL10, RL15 and RL20 as well as W0, W5, Wl0, W15, and W20 according to the day of onset of suckling only 4 pups in restriction lactation and of suckling no pups in weaned group, respectively, in contrast to suckling 8 pups per litter in normal lactation (NL) group. The results obtained were summarized as follows: 1. The serum IGF- I concentration of NL rats was 750.59pm3.52ng/mell on Day 0, which was not changed until Day 15, and then it was increased through the subsequent suckling period to 1690.20pm4.42ng/mell on Day 25. 2. The IGF-I concentrations of early restricted lactation (RL0, RL5) were 1395.90pm3.45ng/mell and 1351pm3.23ng/mell on Day 10, respeotively. It was significantly higher (P＜0.05) than NL group (745.96pm2.24ng/mell), and then was not different between group from day 15 of lactation. 3. The IGF- I concentration of W-group in the early lactation was higher (P＜0.05) than NL group during the first week of lactation. But it was decreased to the similar concentration as NL group on Day 10. These data show that lactation stimulus may regulate the IGF-I concentration.
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KEYWORD
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Insulin-like growth factor- I, Lactation regulation
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